This course encompasses a series of lectures at the nexus of structural biology, biochemistry, and cell biology. An important goal of these lectures, and that of structural molecular biology, is to understand biology in terms of the atoms that carry out its various functions: carbon, nitrogen, and oxygen, phosphorous, sulfur, etc. The so-termed central dogma of molecular biology: DNA makes RNA makes protein serves as the organizing principle of this course. Biological information flows from DNA to RNA to protein. And information in DNA is also replicated. The central importance of the flow of information in biology is indicated by the rigorous control that cells exercise over the underlying biochemical reactions. This course will be implemented in so-termed ‘flipped’ mode. Prior to each class meeting, students will review reading material, listen to lecture videos. Class time will be devoted to discussion/questions about the lecture, review of selected portions of the lecture, problems sets.